Introduction: Herpes (CMV) is recognized because the most typical inborn virus infection in humans and a crucial explanation for morbidity and mortality in upset hosts. This recognition of the clinical importance of invasive herpes virus malady within the setting of immunological disorder and in child with inborn herpes virus infection has light-emitting diode to the event of recent diagnostic procedures for the fast identification of herpes virus. it's calculable that regarding 40,000 child (0.2 to 2%) of all deliveries area unit born with herpes virus leading to regarding four hundred fatalities annually.1 most youngsters (60 to 90%) with symptomatic infection and (10 to 15%) of these with symptomless infection, develop one or additional long-run medicine seqeuls, like subnormality, cognitive content retardation, SNHL and ophthalmologic abnormalities. Objective: To work out the clinical manifestation of inborn herpes (CMV) infection and also the result of Valganciclovir HCL. Methodology: Twenty newborns with inborn herpes virus infection were admitted at Queen Rania Hospital (KHMC) between Gregorian calendar month 2009 and Gregorian calendar month 2010 and were treated with Valganciclovir HCL were enclosed within the study. Result: The most typical clinical presentation was intrauterine growth retardation (45%), Hepatosplenomegaly (35%), Chorioretinites (35%) and purpuric roseola (25%). Brain magnetic resonance imaging was positive in two hundredth. Complete blood count was abnormal in two hundredth. Over seventy fifth patients improved with Valganciclovir HCL with none complications. Conclusion: Intrauterine growth retardation, hepatosplenomegaly and chorioretinites were commonest clinical manifestations of herpes virus infection. Valganciclovir HCL was effective. Hindrance of inborn herpes virus infection by immunisation of symptomatic girls who area unit in danger of primary infection throughout gestation ought to be emphasised.