Introduction: Great saphenous vein is the longest vein in the body begining from the medial end of dorsal venous arch of foot by joining medial marginal vein. It ascend upward and ends by joining femoral vein through saphenous opening in the femoral triangle. Venous drainage of lower limb mainly by the sets of superficial veins and deep veins. Superficial vein include great and small saphenous veins. Superficial veins connected to the deep veins by perforators. Background: As compared to arterial system variations are more commonly seen in venous system. In the superficial veins of lower limbs varicosities are more commonly seen. Aim: To study the variations of Great Saphenous Vein in cadever of South Bihar Population. Methods: Total 32 formaline fixed lower limb were dissected superficially for the study of course, perforators and tributaries of great saphenous vein. Various measurements were taken from saphenofemoral junction to the origin of perforators and tributaries. Duplication of veins were also reported. Results: The mean distance of perforators and tributaries were compared with the previous study and patterns of duplication of GSV were also reported. Conclusion: The present study would be of great help for the managements of varicose vein and also helpful for surgeons and cardiologist as it is used in coronary bypass surgery as autograft.