Aim: The present study was conducted to study the presence of bacteremia, markers of sepsis and Inflammation in renal failure patients on hemodialysis, along with correlation of hematological abnormalities with sepsis in such patients.

Material & Methods: The present study was conducted in the Department of Medicine, Mamata Medical College, Khammam and total of 100 patients of both sexes who were diagnosed as case of renal failure which include both acute kidney injury (AKI) and CKD on basis of clinical history, examination, biochemical markers and were advised for hemodialysis were included in the study.

Results: In our study among 100 patients of renal failure on hemodialysis the mean age in our study was 44.76±14.46 years with 65 male patients. Out of 100 patients 20 (20%) had positive blood and catheter tip culture and 80 (80%) of patients had negative blood and catheter tip culture. Out of 20 patients with sepsis 4 (20%) were in the age group between 15–25 years, 4 (20%) were in the age group between 26–35 years, 3 (15%) were in the age group 36–45 years and 9 (45%) were above 45 years of age. All 20 (100%) patients had episode of fever with chills and rigor, 9 (45%) patients had redness and pain at hemodialysis catheter site, 6 patients (30%) were confused, disoriented or comatose and 4 (20%) patients had hypotension. Among 20 patients of renal failure with sepsis, none had TLC less than 4.8/cumm (leucopenia), 5 (25%) patients had count between 4.8–10.8/cumm and 15 (75%) patients had TLC more than 10.8/cumm.