Colonization and proliferation of bacteria in wound may lead to wound infection. Most of the latter are hospital acquired and usually following an invasive procedure or a surgical intervention. Hospital acquired infections are a world-wide in problem being an important cause of morbidity and mortality among hospitalized patients. A WHO sponsored survey showed that the prevalence of nosocomial infections was 3-21% with wound infections accounting for 5-34%. Therefore the knowledge of infectious agents causing wound infection is necessary for selection of appropriate antimicrobial therapy. Hence from the above findings the present study was planned to evaluate the Bacteriological profile and antibiotic sensitivity patterns of aerobic pus isolates in patients admitted to Anugrah Narayan Magadh Medical College, Gaya, Bihar. The present study was planned in Department of Microbiology, Anugrah Narayan Magadh Medical College (ANMMC), Gaya, Bihar. In the present study 150 pus/wound swab samples (n=2516) received for aerobic culture & sensitivity testing from various department in ANMMC were evaluated and discussed. The study was conducted from June 2018 to April 2019. The data generated from the present study concludes that common organisms isolated from wound infections and it helps in empirical treatment of patients based on antibiotic susceptibility patterns. So the proper care, management and implementation of infection control measures by following strict hand hygiene practices, education about the spread of bacteria through contaminated hands and environment would lead to a decrease in infections with resistant organisms which would be a burden to both the hospital and the patient.