Background: Mechanical Ventilation (MV) has become frequently used life-supportive management in Pediatric Intensive Care Units (PICU). But very little data is available from developing countries regarding the outcome analysis coupled with demographic status and clinical details which is a challenge for the modern day intensivists. Objective: To determine the characteristics and outcome of ventilated patients in the paediatric medical intensive care unit in a Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh. Methods: A prospective descriptive study was conducted on ventilated children admitted to PICU from January to December 2018.The factors studied included demographic and clinical profile, length of stay on ventilator, indications for ventilation and the final outcome. Results: A total of 144 (23%) cases admitted in PICU were ventilated over the period of one year. Male to female ratio was 1.36: 1. Neurological (27.8%) and respiratory (25.6%) causes were found to be the commonest indicators of ventilation in the study. The average ventilator stay was 2/4 days and hospital stay was 7/10 days. 51% of ventilated cases were infants and 81% of total deaths occurred under five years age group.49.3% of ventilated cases were successfully discharged and neurological cases had a better outcome (64%) among all the cases. Conclusion: This study provides an insight into the present status of PICU in a Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh analyses the limitations and recommends the need to strengthen PICU to improve the quality care for the better survival of critically ill children.