Several reports published during these last year’s give an alarm as for the rate of the HIV seroprevalence in Democratic Republic of the Congo. In order to verify the rate of infection to this pandemic in Nord-Ubangi, a documentary study had initiated in the zones of health centers, notably Gbado-Lite, Karawa and Mobayi Mbongo during June 2017. The study shows that the seroprevalence is steady. Out of 947 cases tested for HIV, 39 have been tested HIV positive. A total of 2052 pregnant women are tested to HIV, only 15 women tested positive. We raised 253 new cases of TB among which 16 are tested HIV positive. Thus, the seroprevalence rate rather has the tendency to decrease compared to the previous data collected three years ago. The conditions of people living with the HIV/AIDS improve a lot in this region, thanks to the management of patients subjected to ARV. Yet, the threat remains present, and new infections are more and more recorded. A permanent and efficient sensitization is therefore necessary in order to reduce the impact this pandemic in Nord-Ubangi province.