Introduction: Coma is common emergency encountered by the doctors in casualty department. It is important to triage and manage coma victims promptly and correctly if irreversible brain damage is to be prevented. Numerous scoring systems have been in use for rapid triage of coma victims and assessment of the patients for disease severity and prognosis. Glasgow Coma Scale (GCS) is one of the most widely used scoring systems. Though, GCS has traditionally been used in coma induced by traumatic brain injury (TBI), scale also correlates significantly with outcome in non-traumatic coma (NTC). Aim: This study was conducted to assess the prognostic significance of the GCS in cases of NTC. Material and Methods: The study included 100 patients of NTC admitted in medical intensive care unit of a tertiary care teaching hospital. All cases were studied in detail with respect to history and clinical examination with daily follow up, till discharge or death, to determine the outcome. The profile included assessment of severity of coma by GCS score and evaluation of brainstem reflexes. The outcomes were graded between death and survival. Results: Out of 100 cases of non-traumatic coma, total mortality was 48%. The two most common etiologies leading to mortality in this study are cerebrovascular accidents (CVA) and hepatic encephalopathy. Drug induced coma carried the best prognosis. Conclusion: Poor outcome was associated with low GCS score and absence of brain stem reflexes. Low GCS score formed an independent predictor of outcome.