Historically, there are many types of alternative forms of medicines falling into the category of traditional complementary and alternative medicines (TCAM): traditional Chinese medicine (TCM), Unani, traditional Japanese medicine (TJM), Ayurveda, etc. In the West, one tradition stands out for its use across the millennia: Western Constitutional Medicine (WCM), i.e., Greek-Roman medicine as the foundation of Western medicine. As per traditional Eastern medicine, although difficult to scientifically demonstrate, the principles of WCM through have been experimented on for more than two millennia. Recently a new paradigm shift has rocked the world of biology and promises to change the landscape of medicine too: the concept of the holobiont. Humans are now seen as metaorganisms, a multicellular eukaryote inseparable from its integrated consortia of myriad of species of microbes, mingling together. Among the many applications of this reality view of humans is the idea of eubiosis, or equilibrium of all the species of microorganisms that occupy a specific niche in our body (resident microbiota). The loss of this equilibrium is defined as dysbiosis and results in disease and is akin to the dyskrasis (disequilibrium) of ancient medicine (although different names and systems are used, all are concordant in the path to follow). All treatments devised by TCAMs have the ultimate goal of restoring the natural equilibrium in each individual’s own body (eubiosis of the holobiont). A rebalancing of the interconnected body‑mind-spirit systems in each of these ancient medicines is achieved through the use of various systems but mostly through nutrition. It is herewith proposed that TCAM were much closer to the truth about our biology than is modern medicine. A new medicine (such as personalized medicine) must therefore take on the challenge of integrating this new view of biology. Failure to do so would irreparably separate modern medicine from reality, leaving the path free to TCAMs to fill in this void.