Objective: Literature revealed variety of anaesthetic drugs to blunt stress response of induction and intubation but no standardised premedication protocol exists to minimize cerebral blood flow. ONSD (Optic Nerve Sheath Diameter) is a noninvasive method to measure intracranial pressure. Sevoflurane and Propofol are two well known induction agents in pediatric patients. This study was designed to evaluate the effect of both drugs on optic nerve sheath diameter in glaucoma surgery patients. Methodology: Patients were induced with either Sevoflurane 4-6 %( group S, n=10) or Propofol 1.5 mg/kg (group P; n = 10) inside the operation theatre. The ONSD, haemodynamic response and adverse effects were recorded for 15 min. Results: After intubation HR (Heart rate) in group P was significantly higher as compared to group S at 1,5and 15 min of intubation (p<0.02, 0.004, 0.03). ONSD measured significantly decrease at 5 min of intubation in group P (p< 0.01). In group P there was signifcant decrease in MBP (Mean blood pressure) at 5 and 15 min after intubation. There was no signifcant difference in postoperative nausea vomiting between the two groups. Conclusion: Our findings suggest that Propofol is a preferable agent for induction in glaucoma surgeries.