It has been shown that three port LC, two port LC, Needle scope cholecystectomy with micro-instrument and even single incision LC have shown to be feasible. These new techniques took similar time to perform operation and caused less post-operative pain reducing analgesic requirement, had cosmetic benefits and at the same time reduce the cost of one port, Thus being cost effective than standard LC. Hence the present study was planned to evaluate the observations and complications in three ports vs Classical Four Ports Laparoscopic cholecystectomy. The present study was planned in Department of Surgery, Rama Medical College Hospital and Research Centre, Mandhana, Kanpur, Uttar Pradesh, India from Oct 2010 to May 2011. Total 50 patients were symptomatic gall stone disease were enrolled in the present study. Group I patients were subjected to three-port laparoscopic cholecystectomy and Group II patients were subjected to conventional four port laparoscopic cholecystectomy. From the present study it can be concluded that three port method of laparoscopic cholecystectomy is a safe procedure with no extra complications in the hands of an experienced surgeon. The three port laparoscopic cholecystectomy group is preferable as there is fewer requirements of analgesics, cosmetically better, cost effective and there is less crowding around the operating table as there is no need of second assistant in three port laparoscopic cholecystectomy, thus reducing the required manpower and hospital cost.