Locomotive effect by stem cell after cerebral ischemia in rats
Tae Hoon Lee
We examined that human adipose tissue stromal cells (ATSCs) can be induced to undergo neuronal differentiation. After neuronal induction, the phenotype of hATSCs changed towards neuronal morphology and hATSCs were injected into the lateral ventricle of the rat brain. Transplanted cells migrated to various parts of the brain and ischemic brain injury by middle cerebral artery occlusion (MCAO) increased their migration to the injured cortex. Intracerebral grafting of hATSCs significantly enhances sensory and motor recovery of functional deficits in MCAO rats. These data indicate that transplanted hATSCs survive, migrate and differentiate in the ischemic microenvironment and improve neurological function recovery after stroke in rats. Therefore, we anticipate that transplantation of hATSCs may provide a powerful autoplastic therapy for human neurological injury and degenerative disorders.