International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 5, Issue 8 (2019)

Comparison of the analgesic effect of paracetamol and magnesium sulfate during and after laparoscopic cholecystectomy


Anjna Badhan, Hitesh Gupta

Background and objectives: Magnesium has been proven to have antinociceptive effects which are primarily based on the regulation of calcium influx into the cell, which is natural physiological calcium antagonism and N-methyl-D-aspartate (NMDA) receptor antagonism. Multimodal analgesia, using a non-opioid analgesic in addition to an opioid analgesic, has been suggested as a way to improve postoperative pain control and reduce opioid use [1]. This study compared the analgesic effects of paracetamol and magnesium sulfate. Methods: After taking ethical committee approval 80 patients belonging to ASA grade 1 and 2 who were planned for laparoscopic cholecystectomy surgery were randomly divided into two groups; Group 1 and Group 2. Group 1 received 15mg/kg of intravenous paracetamol and Group 2 received 20mg/kg of intravenous magnesium sulphate immediately after intubation. Pain intensities were measured and recorded using the Visual Analog Scale in the recovery room (0), 1, 3, 6, 9, 12, 18 and 24 hours after surgery. Results: Comparatively Group 2, Group 1 patients had lower post-operative pain and consumed less analgesic drugs during first 24 hours. There is no significant variation in heart rate, systolic and diastolic pressures in both groups. Conclusion: Intraoperative use of paracetamol infusion proved to produce more postoperative analgesia than with use of intravenous magnesium sulphate in laparoscopic cholecystectomy.
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How to cite this article:
Anjna Badhan, Hitesh Gupta. Comparison of the analgesic effect of paracetamol and magnesium sulfate during and after laparoscopic cholecystectomy. International Journal of Medical and Health Research, Volume 5, Issue 8, 2019, Pages 01-05
International Journal of Medical and Health Research