Objectives: To determine the incidence, aetiology and outcome of acute kidney injury (AKI) in hospitalized patients aged 1 month to 15 years. Methods: Conducted among patients diagnosed with AKI (defined according to the Acute Kidney Injury Network criteria), admitted in the pediatric wards and the pediatric intensive care unit (PICU) of a tertiary hospital in northern India. Incidence of AKI (based on the serum creatinine criteria proposed by the AKI Network) and clinico-etiological profile of AKI was studied. Results: The incidence of AKI was 5.6 % in the pediatric wards and 27% in the PICU. AKI occurred in association with infections (58.9 %), acute glomerulonephritis (16.6 %), envenomations (4.1%), cardiac disease (3.7 %), and haemolytic uremic syndrome (3.3 %). Pneumonia constituted 28.9 % of the infections. Renal replacement therapy (RRT) was required in 19.3 % of patients; mortality was 13.6 %. A significant proportion of children had partial renal recovery at discharge. Conclusions: The incidence of AKI is high in the patient population, including the non-critically ill children. AKI continues to be associated with adverse outcomes.