Cholecystitis is a common medical condition where inflammation occurs in gallbladder. This condition can be associated with or without the presence of gallstones. Bacterial infection accounts for 50% to 85% of the disease’s onset. While there is a close relationship between the biliary system and the gut. According to doctrine of Unani Medicine disease occurs in the gall bladder is due to Su-e-Mizaj, Su-e-Tarkeeb or Taffarruq-e-Itteshal. They also mentioned that inflammation occurs in the marara is due to Ghaleez wa Fasid Ghiza, Ehtebas Ghair Tabayi. In Unani system of medicine Usool-e-Ilaj of cholecystis is based on usool-e-ilaj of Amraz-e-Kabid. There are various Unani drugs have been used for the management of Amraz-e-Kabid like Arque Kasni, Arque Mako, Majoon Dabidul Ward, Habbe Kabid Naushadri etc.