Aim: To determine the relationship between fatigue and pulmonary function, exercise tolerance, depression, and quality of life in patients with COPD. Methods: This descriptive cross-sectional study was conducted among 123 patients at MMIMSR, Mullana. Spirometric measures of pulmonary function were carried out in each patient. The Multidimensional Fatigue Inventory was used to measure five subscales of fatigue: general, physical and mental fatigue, reduction in activity, and reduction in motivation. The St. George Respiratory Questionnaire, used to measure quality of life, has three subscale dimensions i.e. symptom, activity and impact as well as an overall or total quality of life score.Results: Mean age was 63.8±2.18, mean FEV₁ was 1.18±0.58 and FEV₁ % predicted was 37.8±18.8. General fatigue significantly correlated with FEV₁, percent predicted (r = -0.32, p < 0.05), exercise tolerance (r = -0.55, p < 0.05), and overall quality of life (r = 0. 75, p < 0.01).