Introduction: Drug Utilization Evaluation play a key role in managing healthcare system to understand, interpret, evaluate and improve the prescribing, administration and use of medications Objective: Most of the antibiotic utilization is empirical leading to their irrational prescriptions. Our present study aims in accessing the drug utilization pattern of Antimicrobials (AMAs) usage in a tertiary care hospital which helps in accessing rationality that aid in monitoring the drug efficacy and other factors related to patient safety. Methods: A prospective observational study was conducted for a period of Six months from March 2019 to August 2019 in the Medicine department at GMC, Azamgarh (UP). Results: A total of 220 prescriptions were analyzed. Among the wide range of AMAs i.e., 825 antibiotics were prescribed where beta-lactams, cephalosporin were found in the maximum number i.e. 264(32%). Around 104 Patients i.e.47.27% was prescribed with two antibiotics, followed by 63(28.63%) patients with three antibiotics. Average numbers of AMAs prescribed were 3.75. Conclusion: Judicious use of antibiotics will reduce the burden of multi-drug resistance, increase better patient compliance and thereby enabling better patient management and limiting the resultant morbidity and mortality.