Aim: To study oxidative stress in psoriasis patients. Material and Methods: A total of 50 cases diagnosed for psoriasis were undertaken during the study period in the test group. 50 healthy individuals with no skin disease were taken as control group. The cases were taken from the department of Dermatology. Blood samples were collected and analyzed in the department of Biochemistry, Owaisi Hospital and Research Centre (OHRC). Results: In this study, serum MDA levels were significantly increased in psoriasis group when compared to controls. Oxidative stress is recognized as important in pathogenesis of psoriasis. Serum FRAP Assay were lowered in psoriasis patients than controls indicating that total antioxidant levels are decreased in psoriasis than controls. Decreased total antioxidant levels may be due to depressed state of antioxidant system or due to oxidative stress in these patients. Conclusion: This study provides an evidence for increased ROS production and decreased antioxidant defenses in psoriasis.