Aim: The effect of intra-lesional infiltration of 2 ml dexamethasone plus hyaluronidase 1500 IU twice a week in the management of patients with Oral Submucus Fibrosis (OSMF) Materials and Methods: The present clinic-observational study was conducted among 100 diagnosed patients of OSMF who attended the OPD of ENT Department, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, India from January 2018 to January 2019. The collected data were subjected to statistical analysis using SPSS version 20 software. Results: Mean age of the study population was 30.02 years. Study shows a definite male predominance (71%). Pre and post mean mouth opening and VAS were found (24.18±2.61, 28.01±3.23) and (6.08±1.28, 3.11±2.11) respectively (p<0.05). Conclusion: The present study concluded that there was significant improvement in mouth opening and also significant reduction in the burning sensation VAS scores before and after treatment.