Aim: Comparison of Ultrasonography (USG) and Computed Tomography (CT) in the evaluation of suspicious Ovarian Masses. Materials and Methods: This prospective observational study was carried out in the Department of Radiology, Darbhanga Medical College and Hospital, Darbhanga, Bihar, India from June 2017 to February 2018. All patients underwent abdominal Ultrasonography and CT scan with determination of the ovarian mass characteristics. Results: We evaluated 100 patients with Mean age of 42.88 years. Most patients belong to 40-50 year age group and followed by 30-40 years. There are total 61 cases of Pre-menopausal stage and 39 cases of Post-menopausal stage having ovarian cyst. Overall, CT was found to have 97% sensitivity, 90% specificity, and an accuracy of 95% in the differentiation of benign and malignant ovarian masses, while PPV and NPV were 96% and 92%, respectively. The sensitivity of USG was 87%, specificity was 85% and PPV and NPV were 86% and 82% respectively. Conclusion: In this present study showed significant differences in the two methods i.e USG and CT. CT is showing more advantages regarding tumor localization, characterization. Hence CT can be advised if the unusual abnormalities were observed in routine USG scan in the diagnosis of ovarian masses.