The study was conducted to examine the Effect of Vedic Mantra Treatment in reduction of Depressive Syndrome and Anxiety. In this study the sample consisted of altogether 40 Hindu adult individual of both sexes aged between 35-50years, suffering from psychological disorder such as depressive syndrome and anxiety. These subjects were identified and selected through purposive sampling technique with the help of diagnostic tests and medical doctor prescription. The subjects were administrated by Goldberg depression test scale (Ivan, k, Goldberg, 2003), and anxiety self-test scale (Elizabeth, Scott, 2011). The result revealed that chanting of Mantra (Maha Mrityunjaya Mantra) has got very important effect on reduction of some psychological disturbances like - depression and anxiety. Hence in medical practice this factor of religiosity and spirituality should be considered and recommended. It would help formulation of new alternative technique of psychological treatment.