Background: Hyperglycemia, the characteristic feature of diabetes, appears to damage tissue by causing both acute irreversible changes in cellular metabolism and cumulative, irreversible alterations in the stable macromolecules such as extracellular matrix components and nucleic acids. Objectives: The objectives of the study is to estimate the level of Trace Elements like Zinc & Magnesium in the Uncomplicated and Complicated cases of Type 2 Diabetes Mellitus. Materials and Methods: The work encloses clinical study on Type 2 Diabetes Mellitus. It is broadly categorized into two parts. The first part comprises of Control group study conducted on 100 healthy control subjects. The second part comprises of Clinical Study, further subdivided into two groups. The first group (Group 1) comprises of 100 newly diagnosed or Uncomplicated Type 2 Diabetic cases and the second group (Group 2) comprises of 100 Complicated (Micro vascular or Macro vascular) Type 2 Diabetic cases. Patients and controls were selected from the outdoor and indoor area of Endocrinology and Medicine Department of M.B. Hospital, R.N.T. Medical College, Udaipur. Subjects of both Group I and II along with control group were analyzed for serum Magnesium, S.Zinc, FBS, PPBS, HbA1C, Lipid Profile and Kidney Function Test. After assessing all the values, Mean and standard deviation of all subjects and parameters are analyzed. Statistical analysis is performed with SPSS software. Comparison of categorical variables (among category comparison) is done using Chi-Square Test. Comparison between cases and control is done by independent student’s t test. By using t value P value is calculated. P value less than 0.05 (P<0.05) is considered significant. Results: Type 2 Diabetic cases (Uncomplicated and Complicated) when compared to Control reflected low significance for Zinc and Magnesium, poor glycemic control, elevated lipid parameters, deranged kidney functions. Males and Females appears to share equal risk of Type 2 DM and its vascular complications picturing the unbigoted nature of the disease. Type 2 DM also attenuates the protective effect of the female sex in the development of cardiac diseases. Conclusion: Our study clearly indicates significant decline in Zinc and Magnesium levels in Type 2 Diabetes and its associated complications. Faulty lifestyle, altered food habits & diminished physical activity culpable for obesity aggravates the pre-existing insulin resistance state. Therefore timely assessing of various minerals at the start and even before the onset of diabetes will be certainly supportive in diabetes management. Towering figure of this epidemic demands varied biochemical approach along with conventional glucose monitoring goals. Hence, our study strongly advocates the regular assessment of Minerals for beforehand diagnosis of the diabetes and its vascular adversities.