Background: UTI, the most common bacterial infection in urinary tract, is a serious health- problem that occurs in millions of people at any age in each year. Its empirical treatment is difficult worldwide. Local susceptibility-pattern of uropathogens is, therefore, important. Aim: To determine the prevalence of UTI, identify common isolates in UTI cases, and there in vitro sensitivity and resistance patterns to common antibiotics. Material & Methods: The midstream urine samples were collected from patients of different age-groups, followed by culture method and determination of antibacterial sensitivity patterns using Kirby-Bauer disc diffusion technique. All the analysis was performed using simple percentage method. Result: Out of 338 samples suspected of UTI 118 samples showed positive growth in MacConkey agar. Antibiotic susceptibility test was done by disc diffusion method. The most frequently isolated uropathogen was E.coli 51% and the antibiotic susceptibility pattern of E.coli was observed. Conclusion: Drug resistance has become a global problem these days. Resistance to the commonly used drugs was high. So prevent the emergence of resistant strains, rational use of drugs is encouraged.