WHO reports in the World Health Report 2002, that of the 35 million health-care workers, 2 million experience percutaneous exposure to infectious diseases each year. It further notes that 37.6% of Hepatitis B, 39% of Hepatitis C and 4.4% of HIV/AIDS in Health-Care Workers around the world are due to needlestick injuries. Many factors involved in transmission of infections due to needle stick injuries which includes overuse of injections, lack of supplies of disposable syringes, safer needle devices, sharps disposal containers, passing instruments from hand to hand while conducting any procedure, lack of awareness and adequate training. Needle stick injuries not only possess health workers at risk of getting infections but also creates an emotional impact which can be severe and long lasting. Hence there is a need of introduction of health teaching programs which can produce positive changes among nurses in knowledge towards safety procedures that can protect them by accidental blood borne pathogen transmission. A total 30 students nurses were recruited randomly. A quantitative study using Quasy experimental, one group pre-test and post-test design were used. Knowledge questionnaire developed by investigator which was used to collect data. The study findings showed that 6 student (20%) had inadequate knowledge towards needle stick injury, 24 student (80%) had moderate knowledge and none of them were having adequate knowledge level regarding needle stick injury.