Silver sulfadiazine is commonly used as a topical cream in burn wound management. Transient leukopenia is a known phenomenon in early post-burn period. The total leukocyte count as well as neutrophil count drop, but recover within 2-3 days. We observed leukopenia in only five out of sixty-two patients with thermal injury early in the course of topical treatment with silver sulfadiazine. Leukopenia in burn patients on treatment with topical silver sulfadiazine application is currently seen as a harmless, self-limited phenomenon. It needs further case control and randomized controlled studies for clarifying its actual cause.