Introduction: Dermatoglyphics are the dermal ridge configuration on the digits, palms and soles. They are genetically determined and influenced by environmental forces that are operating before birth.Aims and Objectives: The aim of this study was to determine the association between digital dermatoglyphics of the hands with cancerous and control groups.Material and Methods: Present study was conducted at SNMC Jodhpur, Rajasthan. Finger and palmar prints were taken from patients suffering from head and neck cancer, undergoing treatment in M.D.M. Hospital, Jodhpur. The Students Studying in Dr.S. N. Medical, Jodhpur served as control.Results and Conclusions: In the present study, we observed that the Main Line Index, the deviation of’t’ does not show any significant difference between controls and cancer subjects.