Musculoskeletal disorder in nursing profession is one of the common occupational health problems worldwide.The design of this study was descriptive cross section. Purposive sampling technique was used. The sample size was 105. Data was collected through face to face interview by using semi structured questionnaire in some selected urban hospitals of Dhaka city.Data was analyzed by SPSS 22 version program. The result of the study showed that among participants, (77.88%) had MSDs. Among 23-32 years respondents has the highest frequency (39%). Nurses mostly affected by MSDs have working experiences in between 10-18 years (39%). Among them (60.47%) participant’s musculoskeletal pain was moderate, The participants who suffered from MSDs 72.94% of them stayed away from work and 88.4% had effect in their performance due to symptoms, 70.6% went to doctors for treatment and 90% diagnosed of disorders.The most common diagnosis was Low back pain (82.5%) and knee joint pain (10%). Among 70.31% of them didn’t relief from symptoms and 48.44% of them had taken medicine while the 46.88% had taken medicine and physiotherapy. 97.6 % respondents thought that contributing factors of their symptoms were working in the same position for long period and more than 80 % thought that performing same work again and again, working in awkward or cramped positions, continuing work during injured or hart were contributing factors. The most common preventative measures suggested by 74.3% participants were changing positions frequently, make appropriate working environment & take rest after 45 minutes respectively. 80% respondents suggested that raising awareness by using mass media, health education about musculoskeletal conditions & necessary screening is essential to prevent MSDs.In future to conduct this type of research large sample size should be taken to generalize the result of the study.