Laryngoscopy during intubation is associated with significant increase in pulse rate and blood pressure. The present prospective randomized comparative study was conducted at Rama Medical College Hospital and Research Centre to assess the efficacy of Nitroglycerine spray 2 puffs (0.8mg) and 10mg Nifedipine sublingual for attenuation of hemodynamic stress responses in patients undergoing intubation for general anaesthesia. These were compared with the patients receiving premedication only.The study found that the use of Nitroglycerine spray(0.8%) administered intranasal 2 minutes and 10mg. Nifedipine sublingual 20 minutes before induction was associated with blunting of the hypertensive effect but not the tachycardia response of the cardiovascular system to laryngoscopy and intubation.