Background and Objectives: Arterial blood gas (ABG) analysis is very useful in evaluation of the underlying disease process in patients admitted to intensive care units (ICU) with respiratory distress. But, arterial puncture may cause unnecessary complications. The aim of this study was to determine whether venous blood gas (VBG) values can be used as an alternative to arterial blood gas measurements in patients of respiratory distress. Methods: This study was conducted at Parul Sevashram hospital on 100 patients admitted to intensive care unit in respiratory distress. Biochemical parameters of venous and arterial blood samples were assessed using the blood gas analysis machine (ABL 80 FLEX). Results: There was a statistically very significant correlation (p<0.05) between all the parameters of ABG and VBG including the pO₂ thus meaning that all the parameters are comparable in emergency situations.