Aim: To compare the findings of ultrasonographic diagnosis of solitary thyroid nodules(STN) by TIRADS classification with histopathological diagnosis. Methodology: 62 euthyroid patient with clinically palpable STN more than 1cm were selected and subjected to detailed ENT including indirect laryngoscopy, systemic Examination and USG by TIRADS classification.They were subjected to definitive surgical procedure i.e Hemithyroidectomy or Total Thyroidectomy. Post-operative specimen was sent for histopathology. Data obtained was analysed using appropriate statistical test and inference drawn. Result: We found that Sensitivity, specificity of USG by TIRADS classification for differentiating benign and malignant thyroid nodule were 85.7% and 96.36% respectively. Conclusion: TIRADS classification is simple practical method of accessing thyroid nodule with high PPV for malignancy and justified on routine basis for management of STN.