Objective: To evaluate CD10 expression in urothelial bladder carcinoma and the association of CD10 intensity with grades and stages. Materials and methods: Thirty consecutive cases of urothelial bladder carcinoma, obtained through transurethral resections, were included in this study. Haematoxylin-eosin (HE) stained sections from each case were evaluated histopathologically according to WHO 2004 grading system. The TNM system was used for pathological staging. CD10 marker was applied and a semi quantitative scoring for its expression based on the percentage of positive cells and intensity was performed. Data was entered and analysed on SPSS version 17. Fisher’s exact test was used to compare grades, stages of urothelial carcinoma with CD10 expression and age group. P <0.05 was taken as level of significance. Results: Urothelial carcinoma is more common in males. The male to female ratio was 5:1. The older patients >50 years had higher grades and stages as compared to the younger patients. All cases of high grade urothelial carcinoma showed higher positivity for CD10 expression. Fourteen cases (77%) of high grade urothelial carcinoma were positive with +2 immunostaining while four cases (22%) were positive with +1 staining. Of total nine cases pTa, three cases (33%) were negative and six cases (66%) were positive with +1 staining. Of all the cases of pT1 tumour, 1 case (6.6%) was CD10 negative, 5 cases (33%) were CD10 positive having +1 staining and 9 cases (60%) were CD10 positive having +2 staining. Out of all the patients with stage pT2 no tumour was CD10 negative, 1 case (16.6%) were Cd10 positive with +1 staining and 5 (83.3%) with stage pT2 tumour had staining positive with +2 staining.