Aim: to study the prevalence of postpartum depression and its associated risk factors at a tertiary care teaching hospital in India. Methods: This descriptive cross-sectional study was carried out at Jawaharlal Nehru Medical College, Aligarh Muslim University, U.P, India. The postpartum mothers, who received antenatal and postnatal care in this hospital, were recruited for the study. The validated Edinburgh Postnatal Depression Scale questionnaire was used to measure postpartum depression. A cut-off score of 12 was considered to indicate probable depression. Results: Out of a total of 408 women participated in this study, 26.9% had a score of 12 (Probable Depression). The multivariate analysis showed that postpartum depression was significantly associated with gender associated factors, history of depressive episode, and lack of family support. Conclusions: The study confirms that gender-based factors are important determinants of postpartum depression followed by previous history of depressive episode and the husband’s perceived lack of social support emerging as associated risk factors