International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 6, Issue 3 (2020)

Alpha: Glucosidase inhibitor and its relevance in prediabetes: An observational study


Dr. Gururaj Krishnarao Kulkarni

Aim: Importance of Alpha- glucosidase inhibitor in high risk patients and prediabetes patients. Aim of study is to show multiple way approach helps in achieving glycemic control in prediabetic patient and it can delay the patients from developing frank diabetes mellitus with multifactorial approach. Material and Methods: In the present study a total of 210 prediabetic patients were selected out of which only 50 participants were eligible for study. Inclusion Criteria: 1) Age: 28-68yrs, 2) FBS: 101-125mg/dl, PPBS: 141 -199mg/dl, 3) BMI: 23-28 4) HbA1c: 5.7-6.4%. Exclusion Criteria: 1) Known Diabetic 2) Any Past history of Diabetic drug intake 3) Preexisting CAD, Renal Dysfunction, Hepatic Dysfunction, Gastro-intestinal Disorders. Results: 50 eligible patients were enrolled as per Inclusion criteria, they were divided into two groups, Group A was placed on Diet, lifestyle modification and Voglibose 0.2mg twice a day, whereas the Group B was placebo group. In group A, there were 12 males (46.15%), and 14 female subjects (53.84%), whereas in the placebo arm, there were 10 males (41.66%), 14 Female (58.34%). It was observed that patients on alpha glucosidase inhibitors had better glycemic control than placebo group arm. The glycemic level in Group A was in normoglycemic range with alpha glucosidase inhibitors and diet and lifestyle modification than compared to placebo arm group Conclusion: Usage of α glucosidase inhibitor is higher in Asian countries. It is emerged as the alternative to metformin in management of prediabetes patients. In emerging countries like India it is been used vastly in patients with post prandial surge in glycemic levels. It is now proven that these drugs are novel drugs should be used as the alternative to metformin in selected patients. Further, randomized cross trials and large population based studies are required. The limited small study has shown significant reduction of glycemic level in prediabetic patients.
Download  |  Pages : 04-05
How to cite this article:
Dr. Gururaj Krishnarao Kulkarni. Alpha: Glucosidase inhibitor and its relevance in prediabetes: An observational study. International Journal of Medical and Health Research, Volume 6, Issue 3, 2020, Pages 04-05
International Journal of Medical and Health Research