Introduction: Surgical site infection (SSI) is the third most frequently reported nosocomial infection that accounts for 14% to 16% of all nosocomial infections among hospitalized patients. Patients with SSIs are 2-11 times higher risk of death, compared with operative patients without SSI. Aims and Objectives: This study aimed to determine the surgical site infection rate during hospitalization and also in post-discharge. Materials and Methods: A descriptive study was conducted, comparing surgical site infection rates during hospitalization and the impact of post discharge reports through different methods in Marks Medical College & Hospital, Dhaka, Bangladesh. Results: During patients’ stay at Hospital, 2% of infections were detected before the 7th day after surgery. Regarding post-discharge detection, in hospital, the highest infection rates were found before the 14th day after surgery; 14%. Conclusion: The reliable SSI rates can be observed by performing follow up during hospitalization and also after discharge which help in implication of preventive measures.z