International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 6, Issue 3 (2020)

Assessment of prevalence of microalbuminuria as a nephropathic marker in patients suffered from type 2 diabetes mellitus and its correlation with the glycated hemoglobin


Dr. Kavita Priyadarshani, Dr. Anupma Priyadarshini, Dr. Farhan Usmani

Diabetic nephropathy is the leading cause of end-stage renal failure in patients with Type 2 DM, and its prevalence is increasing annually worldwide. Compared to 20 years ago, the incidence of diabetic complications without diabetic nephropathy has decreased; however, is still the main complication in diabetes. Microalbuminuria is defined as levels of albumin ranging from 30 to 300 mg in a 24-hrs urine collection. Microalbuminuria was the strongest predictor of cardiovascular events in a high-risk population with underlying atherosclerosis. It was found to be stronger than other risk factors such as coronary artery disease and diabetes. Microalbuminuria does not directly cause cardiovascular events; it serves as a marker for identifying those who may be at increased risk. Microalbuminuria is caused by glomerular capillary injury and so may be a marker for diffuse endothelial dysfunction. Hence based on above findings the present study was planned for Assessment of Prevalence of Microalbuminuria as a Nephropathic Marker in Patients Suffered from Type 2 Diabetes Mellitus and its Correlation with the Glycated Hemoglobin. The present study was planned in Department of Biochemistry, Patna Medical College, Patna, Bihar, India. Total 40 cases were enrolled in the present study. The 20 cases were enrolled in Group A as cases of diabetes mellitus and 20 cases were enrolled in Group B as control cases for comparative study. The data generated from the present study concluded that estimating glycosylated hemoglobin as an indicator of glycaemic control and microalbuminuria in random urine sample for renal involvement in diabetic subjects provide a convenient method for early diagnosis and intervention. Hence the microalbuminuria is nephrotic market in cases diagnosed with the diabetes mellitus. Hyperglycemia is the major factor initiating the changes in the kidney. The tissue damage caused by hyperglycemia can be attributed to the hemodynamic factor, glycosylation of tissue proteins and increase activity of the polyol pathway.
Download  |  Pages : 98-102
How to cite this article:
Dr. Kavita Priyadarshani, Dr. Anupma Priyadarshini, Dr. Farhan Usmani. Assessment of prevalence of microalbuminuria as a nephropathic marker in patients suffered from type 2 diabetes mellitus and its correlation with the glycated hemoglobin. International Journal of Medical and Health Research, Volume 6, Issue 3, 2020, Pages 98-102
International Journal of Medical and Health Research