Evaluation of different low dose of aspirin therapy on renal function in elderly patients
Dr. Sunil Kumar, Dr. Hemshanker Sharma
Low dose aspirin is commonly used by elderly people for the prevention of thrombosis. These individuals are more prone to non-steroidal anti-inflammatory drug and aspirin-related adverse reactions, including renal side effects. The effects of the current low dose aspirin regimens (75–325 mg/day) in this regard were previously studied in two cohorts of elderly patients. It is found that these doses of aspirin were capable of inducing a significant decrease in both creatinine and uric acid excretion within 1–2 weeks. One week after the drug was withdrawn, uric acid excretion returned to normal while creatinine clearance remained low. The consistency of these findings and their potential significance and the mechanisms underlying these effects warrant further research. Hence based on above findings the present study was planned for Evaluation of Different Low Dose of Aspirin Therapy on Renal Function in Elderly Patients. The present study was planned in Department of General Medicine, Jawaharlal Nehru Medical College Bhagalpur, Bihar, India. Total 30 patients of both sexes were evaluated in the present study. The patients were divided in two study groups as Group A and Group B. The 15 cases in Group A patients received the received 100 mg/day Aspirin for 4 weeks and in 15 cases in Group B patients received the 300 mg/day Aspirin for 4 weeks. The data from the both the study group patients were analysed and evaluated. The data generated from the present study concludes that 300 mg/day aspirin was found to induce a considerably higher changes in renal function and secretion of uric than 100 mg/day. The dosage of 100 mg/day aspirin can be used with more safety during the treatment.
Dr. Sunil Kumar, Dr. Hemshanker Sharma. Evaluation of different low dose of aspirin therapy on renal function in elderly patients. International Journal of Medical and Health Research, Volume 6, Issue 3, 2020, Pages 137-141