Comparative evaluation of thyroid hormone abnormalities in septic neonates from Darbhanga, Bihar
Dr. Shaantanu Kumar, Dr. Nagendra Prasad Gupta, Dr. Satyendra Paswan
The role of thyroid hormones in neurologic development of newborn has been elucidated & absence of adequate hormones as occurs in congenital hypothyroidism result in adverse neuro-developmental outcome. Currently the neonatal screening for congenital hypothyroidism is performed in all developed countries as well as few developing countries. Advances in diagnostic techniques and therapeutic intervention are designed to enhance the overall outcome of the ever-increasing number of surviving premature and critically-ill infants. According to National Neonatal Perinatal Database (NNPD) 2000 neonatal sepsis is the most common cause of deaths in the country followed by prematurity & birth asphyxia. Hence based on the above findings the present study was planned for Comparative Evaluation of Thyroid Hormone Abnormalities in Septic Neonates from Darbhanga, Bihar. The present study was planned in Department of Paediatrics, Darbhanga Medical College and Hospital, Laheriasarai, Darbhanga, Bihar, India. The two groups of neonates of diagnosed with the neonatal sepsis and Control neonates were enrolled in the present study during the period of July 2019 to december 2019. The 25 neonates diagnosed with the neonatal sepsis were enrolled in Group A as Cases group. The Control group consist of 25 neonates without any complications. The data generated from the present study concludes that Sick newborns have significantly increased TSH levels compared to the healthy newborns, indicating a subclinical Hypothyroidism in the former groups. Further studies are required on larger sample size to substantiate the findings and should aim to clearly establish the strength of the above-mentioned association in neonates with sepsis whether thyroid supplementation during initial course of NICU stay can affect the outcome, among neonates with severe sepsis need to be systematically evaluated.
Dr. Shaantanu Kumar, Dr. Nagendra Prasad Gupta, Dr. Satyendra Paswan. Comparative evaluation of thyroid hormone abnormalities in septic neonates from Darbhanga, Bihar. International Journal of Medical and Health Research, Volume 6, Issue 3, 2020, Pages 159-163