Aim and objective: To determine the utility of CA125 and CA19.9 in early diagnosis and risk stratification of ovarian cancer alone and in combination Material and methods: It is a cross sectional study comprising of 100 subjects, 60 patients of ovarian carcinoma and 40 normal healthy volunteers. Serum samples were collected to investigate the level of CA 125 and CA19.9 by CLIA method. Results: CA 19.9 and CA 125 was significantly elevated in ovarian carcinoma (91.47±52.6 and 189±33.2 U/L).Sensitivity of CA125 was 62.1% and specificity of CA19.9 was 79%. Sensitivity and specificity when both the tumor markers combined was 94.2% and 87.5% Conclusion: Combination of CA 125 and CA 19.9 can be used as tumor marker for early diagnosis of malignant ovarian carcinoma.