Background: Many patients with cancer experience pain either during or after treatment. It is critical that healthcare providers, in all settings possess the knowledge and skills to assess and manage cancer related pain. Objectives of the Study: 1.To assess the knowledge of staff nurses regarding cancer pain management before administration of information booklet.2.To assess the knowledge of Staff nurses after administration of information booklet.3.To determine association between posttest knowledge scores and demographic variables of staff nurses Material and Method: The study was carried out in oncology wards of Sher e Kashmir Institute of Medical Sciences, Kashmir from 2nd December to 14^th December 2013. 50 staff nurses working in oncology wards were selected.Their knowledge regarding cancer pain management before and after the administration of information booklet was assessed and the association between posttest knowledge scores and demographic variables of staff nurses was studied. Statistical analysis was done by‘t’ value test, Fisher exact test, and c² test using SPSS software. Results: In the pretest, out of 50 subjects, majority of them 39(78%) had inadequate knowledge, 11(22%) had adequate knowledge and none of the subject had highly adequate knowledge. In the posttest majority of them 33 (66%) had highly adequate knowledge, 17(34%) had adequate knowledge, and none of the subject had inadequate knowledge There was a significant difference in the mean pretest and posttest knowledge scores (with a t value. 24.97, which is highly significant at the level of p<0.001). Conclusion: The study revealed that initially the nursing personnel had a low level of knowledge on cancer pain management After exposing them to information booklet, subjects’ mean post-test knowledge scores was significantly higher than the mean pre-test knowledge scores. So, it is recommended that cancer pain should be managed better through adequate assessment, using appropriate pharmacological and non-pharmacological interventions, with reassessment of outcomes of intervention and accurate documentation