Background: Chronic kidney disease (CKD) is recognized as a major health dilemma affecting a greater proportion of people across the world. As we all know that the early detection is important to prevent further injury and progressive loss of renal function. Under the light of such intermingling evidences, we planned the present study to assess the knowledge of outpatients in relation to CKD. Materials & Methods: The present study included assessment of knowledge of outpatient’s clinic patients in relation to chronic kidney diseases. A total of 200 patients were included the present study. A pre-framed questionnaire was given to all the subjects. All the questions were assessed and analysed by experienced subject expert and physicians. All the results were analysed by SPSS software. Results: A total of 200 subjects were included in the present study. 40 and 45 patients belonged to the age group of 25 to 35 years and 36 to 45 years respectively. Significant results were obtained while comparing the mean knowledge score of the subjects divided on the basis of their age. Males had significantly more knowledge of CKD in comparison to females. We also observed an increase in the knowledge of subjects in relation to CKD with a corresponding increase in the level of education of the subjects. Conclusion: Within the limitation of the study, the author concluded that the existing level of knowledge among the studied patients was at lower levels.