Controversies have emerged regarding the effect of Renin-angiotensin-system (RAS) inhibitors on ACE2 regulation and SARS-CoV-2 infection progression in this pandemic. Several countries including India are reporting SARS-CoV-2 infection in huge numbers of asymptomatic carriers. I propose that plasma renin activity (PRA) level may act as a significant pathophysiologic marker to determine the fate of SARS-CoV-2 infection.