Management of non-vital teeth with open apices is always a challenge to the dental practitioners. Treatment options comprise conventional apexification procedure with or without apical barriers. One of the disadvantages of conventional apexification using calcium hydroxide is the need for long term therapy to enable barrier formation. In order to overcome that, calcium silicate-based cements like MTA and Biodentine were introduced which enables a single visit apexification. This case series observes apexification and successful healing with the use of Biodentine as an apical barrier matrix in root end apexification procedure.