Diabetic foot is defined as the sore that develops in the foot that develops due to microvascular and macrovascular complications including failure of wound healing process and is the most common problem of diabetes mellitus. The risk factors for development of diabetic foot are Diabetic Neuropathy, Peripheral Vascular Disease, Cigarette smoking, Poor glycemic control, Previous ulceration and Previous Amputation. The altered metabolism of glucose results in abnormal formation of granulation tissue thereby delays wound healing. Secondly, Nitric oxide is an important stimulator of cell proliferation, maturation and differentiation which also increases fibroblast proliferation and thereby collagen production in wound healing. Hence, impaired nitric oxide synthesis will delay wound healing process. Fibroblasts from diabetic ulcer exhibit proliferative impairment that perhaps contributes to a decreased production of extracellular matrix proteins that delay wound contraction and impaired wound healing. Diabetic foot problems are wider and several systems including vascular, nervous, somatosensory and musculoskeletal systems have been involved. The biomechanics happens due to effects on skin, tendons and ligaments, effects on cartilages, effects on muscles, effects on peripheral sensory system, and effects on foot morphology. Diabetes Foot Assessment includes Complete History, Duration of illness and treatment received, Glycemic control, Diabetes complications, if any, History of heart disease, History of wound formation and treatment type, Wound healing process, History of amputation and surgery, History of Smoking, Life style habits, exercise pattern, Neuropathic symptoms, if any, Vascular symptoms, if any. Management principles include Wound Dressing, Infection Control practice, Antibiotics, Offloading, Rest, Elevation of affected foot, Relief of pressure Ultrasonic debridement, Topical growth factors, honey dressing, phenytoin dressing, platelet rich plasma therapy, Bioengineered skin grafts(BATs),VAC (Vacuum Assisted Closure) Therapy, Hyperbaric oxygen therapy(HBOT), Stem cell therapy etc. Prevention is the gold standard and every efforts and care should be taken to prevent the diabetic foot by Optimal diabetes control, Effective local wound care, Infection control, Pressure relieving strategies, Restoring pulsatile blood flow. The limb salvage is the priority and this article highlights the pathogenesis, treatment options and preventive steps in this modern era.