International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 7, Issue 12 (2021)

Moderately differentiated Sertoli-leydig cell tumour in a teenager: Report of an unusual diagnosis in an unilateral ovarian cyst


Sophia Merilyn George, Reena Rahayu Md Zin, Barani Karikalan

Mixed type Sertoli – Leydig cell tumours are uncommon ovarian neoplasms of sex – cord stromal origin accounting for less than 0.5% of ovarian neoplasms. Patients commonly present in their second and third decades of life with symptoms of abdominal mass or with hormonal changes, commonly androgenic features like virilization and defeminization. DICER 1 mutations present in younger patients with syndromic association. FOXL-2 have also been documented. Immunohistochemical evaluation show Sertoli cells exhibiting positivity for calretinin, inhibin, FOXL2, SF1 and WT1. The Leydig cells usually exhibit Melan A and inhibin. Prognosis depends on staging (FIGO and TNM) and grading (differentiation). Associated heterologous elements such as cartilaginous or skeletal muscle differentiation confer an unfavorable prognosis also. The mainstay of treatment is surgical, adjuvant chemotherapy may be offered in certain scenarios. We present a case of Mixed type Sertoli – Leydig cell tumour in a young patient, which coupled with the cystic nature of the tumour, posed a diagnostic challenge as these tumors are extremely rare.
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How to cite this article:
Sophia Merilyn George, Reena Rahayu Md Zin, Barani Karikalan. Moderately differentiated Sertoli-leydig cell tumour in a teenager: Report of an unusual diagnosis in an unilateral ovarian cyst. International Journal of Medical and Health Research, Volume 7, Issue 12, 2021, Pages 31-33
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