International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 7, Issue 12 (2021)

Brain-derived neurotrophic factor (BDNF) val66met polymorphism influences clinical and neurocognitive outcomes in patients with mild to moderate traumatic brain injury


Sutopa Roy, Anindita Joardar, Sarnava Roy, Shubhamitra Choudhary, Subhashis Ghosh, Samarendra Nath Ghosh

Aim: Traumatic Brain injury (TBI) is a major cause of injury and death annually in India. Most patients who sustain a mild or moderate head injury recover within weeks to months. Genetic variation in the Brain Derived Neurotrophic Factor (BDNF) gene among such individuals might be the cause of differential response and recovery from TBI. In our study, BDNF gene was examined in patients with TBI in order to see if a correlation could be found between BDNF Gene polymorphism and the extent of recovery from mild to moderate TBI. This study is a first of its kind in India. Materials and methods: A Total of 115 patients who had suffered from mild to moderate head injury and who were admitted to the hospital emergency ward were enrolled in the study. On consent of the patients, 5 ml venous blood samples were collected from them and preserved in EDTA at -20°C. Polymerase Chain Reaction followed by Restriction Fragment Length Polymorphism and Agarose Gel Electrophoresis were used to genotype the BDNF gene and determine the allele types. They were then assigned a category based on the Glasgow Coma Scale through interviews and examination. Six months follow up data was available for 115 patients. Results: A protective effect of the G allele in the gene with better performance in attention, executive function, memory, and overall cognition among patients with mild and moderate TBI was observed. Conclusions: Our current study has demonstrated the role of the BDNF rs6265 Val66Met polymorphism in influencing clinical and neurocognitive outcomes in patients with mild and moderate TBI, where Met allele carriers had considerably low standard scores in clinical & cognitive domains.
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How to cite this article:
Sutopa Roy, Anindita Joardar, Sarnava Roy, Shubhamitra Choudhary, Subhashis Ghosh, Samarendra Nath Ghosh. Brain-derived neurotrophic factor (BDNF) val66met polymorphism influences clinical and neurocognitive outcomes in patients with mild to moderate traumatic brain injury. International Journal of Medical and Health Research, Volume 7, Issue 12, 2021, Pages 37-41
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