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VOL. 7, ISSUE 4 (2021)
A comparative study of antioxidant status in patients on haemodialysis and healthy control subjects
Authors
Geeta Rawal, Yogita Soni, Amit Singh Rawal
Abstract
Chronic renal failure is a progressive loss of renal function over a period of months or years. Chronic Kidney Disease (CKD) encompasses a spectrum of different patho-physiological processes associated with abnormal Kidney functions and a progressive decline in glomerular filtration rate (GFR). This study aims to estimate the levels of serum Malondialdehyde (MDA), Urea and Albumin in healthy control subjects and in patients with chronic renal disease undergoing haemodialysis. This was a prospective hospital based, case-control study conducted on 100 individuals aged between 25-75 years of both sexes, 50 cases were taken from Nephrology Department (Dialysis Unit) as study group and 50 controls were healthy individuals in PBM hospital during 2019. Blood samples of control as well as study group were withdrawn and analyzed. The serum MDA, were estimated by UV-VIS spectrophotometer. The serum Albumin, and Serum Urea were estimated by fully autoanalyser. The results of present study showed that in CKD patients under-going haemodialysis serum MDA was significantly increased (P-value <0.0001). and Serum urea also increased whereas serum albumin level decreased in haemodialysis patients. The results may be significant in understanding the possible contribution of above mentioned parameters in pathophysiological process of CKD, and role of antioxidants in patients on haemodialysis. This study may help us to optimize antioxidant supplementation as adjuvant therapy in treatment of renal disorder patients who are on haemodialysis, which will help in preventing the impending complications caused by progression of disease and subsequent Haemodialysis.
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Pages:10-12
How to cite this article:
Geeta Rawal, Yogita Soni, Amit Singh Rawal "A comparative study of antioxidant status in patients on haemodialysis and healthy control subjects ". International Journal of Medical and Health Research, Vol 7, Issue 4, 2021, Pages 10-12
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