Introduction: Cardiovascular disease has become a leading cause of disability and premature mortality globally. According to the Global Burden of Diseases, Injuries, and Risk Factor Study 2015, cardiovascular disease affected an estimated 422·7 million people and caused an estimated 17·9 million deaths worldwide in 2015, comprising 31% of all global deaths [1]. Dyslipidemia is an important atherosclerotic risk factor. Dyslipidemia is a multifactorial disorder, which arises from complex interactions among genetic and environmental risk factors [2]. The NCEP ATP III Classification defines LDL cholesterol levels less than 100 mgdl as optimal, Total Cholesterol level less than 200 mgdl as desirable and HDL Cholesterol between 40 to 60 mgdl as normal [3]. There is an emerging evidence of premature coronary artery disease occurring in Asian Indians at least 10 years earlier as compared to other ethnic groups. Several studies in the recent past have suggested total cholesterol, Low Density Lipoproteins (LDL), triglycerides levels have increased among young urban populations. The primary objective of our study was to investigate the dynamic trends in total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels with ageing. Methods: This is a descriptive cross-sectional study carried out on patients visiting OPD of Department of General Medicine. Patients were divided into 3 groups with age 18 year to 40 year, 41 year to 60 year and >60 year by involving 1989 subjects of whom 532 were between 18 year to 40 year, 935 were between 41year -60 year and 522 were over 60 year of age. This study included measurement of fasting serum lipid profile consisting of total cholesterol, Low Density Lipoprotein, Triglycerides & High Density Lipoproteins. Results: The study revealed higher prevalence of dyslipidemia in the group <60 year. Mean cholesterol was high in age group 18 – 40 years. The highest mean triglycerides was found in the age group between 41-60 years. The highest mean HDL levels was found in the age group above 60 years. Statistically significant difference in mean was found with cholesterol, LDL, triglycerides between the age group of 18- 40 years and more than 60 years. Statistically significant difference was not found between 18 – 40 years and more than 40 years to 60 years for HDL Conclusions: Higher percentage of dyslipidemia was found in the age groups less than 60yrs. Age related trends in lipid levels according to sex are essential for ‘precision medicine’.