Reactive arthritis most commonly occurs following an episode of gastroenteritis by Yersinia, Salmonella, Shigella, Campylobacter, and Clostridium difficile or a genitourinary infection by Chlamydia trachomatis and Neisseria gonorrhea. Reactive arthritis due to other atypical organisms in HLA-B27 negative patients is often missed to lack of suspicion. This case report presents a case of recurrent reactive arthritis caused by an asymptomatic urinary tract infection by E.Coli in a female patient with HLA-B27 negative. The diagnosis was delayed due to atypical organism and presentation. This case report aims to highlight the need for a high degree of suspicion for reactive arthritis in cases of urinary tract infection by E.Coli.