Background: Acne vulgaris is a common disorder, with inflammation of the pilosebaceous units that morphologically presents with Comedones, inflamed papules, pustules and nodules. A lthough its physical and psychosocial impact is studied in teen years, it is poorly understood in the Indian adult population. Aim: To study the physical and psychosocial impact of acne in adult females. Settings and Design: This exploratory study was done in the Medical college setting. Materials and Methods: Twelve adult, unmarried females, between the age group of 18 and 25 years, having (mild-to-moderate), acne, for two consecutive years, were interviewed using a semi-structured clinical interview of the Skindex, a quality-of-life measure for patients with skin disease, developed by Chren et al., along with some open-ended questions. Both qualitative and quantitative analysis was done to analyze the data. Result: The results indicated a higher level of emotional and social impairment, in terms of the feelings of physical discomfort, anger, and the intermingling impact of these, among the participants. Conclusion: Acne is a common problem among adults and appears to have a considerable impact on the mental health, therefore, for the treatment to be successful, a sympathetic approach by doctors and significant others, with the basic psychosomatic treatment, are necessary.