International Journal of Medical and Health Research

International Journal of Medical and Health Research


International Journal of Medical and Health Research
International Journal of Medical and Health Research
Vol. 8, Issue 6 (2022)

Correlation between serum vitamin D3 levels and infarct volume in acute ischemic stroke patients: A cross sectional study


M S Siddiqui, Dr. Tushar Tyagi

Background: Vitamin D3 levels have been shown to have an association with severity, outcome, and infarct size in acute ischemic stroke patients. The association of vitamin D3 levels with infarct size and prognostic significance of vitamin D3 levels as a surrogate prognostic marker of outcome in acute ischemic stroke patients needs to be evaluated further, especially in Indian patients. Methodology: The study was a cross sectional study conducted at the Department of Medicine, Era's Lucknow Medical College & Hospital, Lucknow on 65 admitted patients with acute ischemic stroke. Infarct volume was measured and laboratory parameters like vitamin D3 levels, lipid profile and glycaemic parameters were assessed on the first day of admission. Results: The mean age of the patients was 58.82±12.47 (Range - 23-82) years. There was a male preponderance (66.20%) and most of the patients were overweight or obese. Hypertension (72.30%) and diabetes (53.80%) were the most common comorbidities. The mean vitamin D3 levels were 37.81±25.00 nmol/L with a range of 7.5-150 nmol/L. Most of the patients were either Vit D3 deficient (28, 43.10%) or severely deficient (20, 30.80%). Most of the infarcts were ≤10 cc (41.50%) or >30 cc (32.30%) in volume with a mean volume of 51.71±81.66 cc. Volume of stroke and Vitamin D3 level were found to be inversely correlated with a Pearson’s corelation coefficient of -0.201. A higher vitamin D3 level was observed among patients with lower infarct volume and a higher infarct size was observed among severe vitamin D3 deficient patients. None of the trends were significant statistically (P>0.05). The only significant variable between the groups based on vitamin D3 status was in terms of positive family history of cerebrovascular disease. Conclusion: Vitamin D3 deficiency was highly prevalent in stroke patients yet was unrelated with major clinical and demographic variables including the infarct size.
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How to cite this article:
M S Siddiqui, Dr. Tushar Tyagi. Correlation between serum vitamin D3 levels and infarct volume in acute ischemic stroke patients: A cross sectional study. International Journal of Medical and Health Research, Volume 8, Issue 6, 2022, Pages 1-5
International Journal of Medical and Health Research