This analysis focuses on the acute GIT bleeding. It is one of the most urgent conditions in gastroenterological practice, with a total mortality rate of about 10%. It can present itself as bleeding from the upper and lower gastrointestinal tract. There are risk prognostic scales to assess the chance in the 30-day adverse risk events (e. g., mortality, rebleeding, and surgical intervention): Glasgow-Blatchford Bleeding Score, Rockall Score, AIMS65, Charlson Comorbidity Index CCI. The Charlson Comorbidity Index is a method for categorizing a patient's comorbidities and predicting long-term mortality. A point system (from 0 to 6 points) is used for each category of comorbidity. It predicts in percentages the probability of whether or not the patient will survive in the next 10 years. A study was conducted, based on existing literature, on the relationship between comorbidity, risk of GI bleeding, and long-term prognosis. Comorbidities have been found to influence bleeding risks and long-term prognosis, but the Charlson index is unreliable and cannot be used alone as a predictor of bleeding outcome and its complications (conversion to surgery, persistent bleeding, and hemotransfusion).